In Vitro Safety Assessment of Whey Hydrolysates

Antibody mediated allergy to Cow's milk can form a major threat to the infant's health. Infants with this type of allergy cannot consume normal milk from cow origin. Cow’s milk-derived whey hydrolysates are nutritional substitutes for children with this type of allergy. These hydrolysates can be regarded as degraded proteins of which the fragments will no longer to be recognized by the immune system of the allergic child. Cow's milk (or more specifically whey) hyrolyses therefore, will not trigger an allergic reaction. For the safety of the infant it is important to assess any residual allergenicity of the hydrolyses, before using these in infant food.

3R methods

One of the most important spin-offs of our current research is the development of methods potentially suitable to replace or reduce the use of animals in Life Sciences. Animal experiments in science are necessary to gain mechanistic insight into biological processes, to assess (risk to) hazard of potentially harmful effects of chemicals and pharmaceuticals to humans and animals, and to ascertain the potency and safety of biologicals and vaccines. Every animal experiment performed in the Netherlands is done under rules and regulations that are decribed in the Dutch Act on the Welfare and Use of Animals for Sciences (Wet op de Dierproeven en Het Dierproevenbesluit). Currently, national laws of all the member states of the European Union are being revised and brought in line with the new EU Directive on on the protection of animals used for scientific purposes.