Publications

2016

Poland M, Ten Klooster JP, Wang Z, Pieters R, Boekschoten M, Witkamp R,
Meijerink J. Docosahexaenoyl serotonin, an endogenously formed n-3 fatty
acid-serotonin conjugate has anti-inflammatory properties by attenuating
IL-23-IL-17 signaling in macrophages.
Biochim Biophys Acta. 2016 Sep 20. pii:
S1388-1981(16)30249-9. doi: 10.1016/j.bbalip.2016.09.012. [Epub ahead of print]
PubMed PMID: 27663185.

 

Woutersen RA, Soffers AE, Kroese ED, Krul CA, van der Laan JW, van Benthem J,
Luijten M. Prediction of carcinogenic potential of chemicals using repeated-dose
(13-week) toxicity data.
Regul Toxicol Pharmacol. 2016 Sep 8;81:242-249. doi:
10.1016/j.yrtph.2016.09.003. [Epub ahead of print] PubMed PMID: 27614137.

 

Blaauboer BJ, Boobis AR, Bradford B, Cockburn A, Constable A, Daneshian M,
Edwards G, Garthoff JA, Jeffery B, Krul C, Schuermans J. Considering new
methodologies in strategies for safety assessment of foods and food ingredients.

Food Chem Toxicol. 2016 May;91:19-35. doi: 10.1016/j.fct.2016.02.019. Epub 2016
Mar 3. Review. PubMed PMID: 26939913.

 

Knipping K, van Roest M, Kruijssen L, Smits M, Teunis M, Cox L, de Jong N,
Simons PJ, Boon L, Teshima R, Gros M, Kegler D, Garssen J, Knippels LM, Pieters
R
. Intra- and inter-laboratory validation of an innovative huFcεRIα-RBL-2H3
degranulation assay for in vitro allergenicity assessment of whey hydrolysates.

Toxicol In Vitro. 2016 Jun;33:29-34. doi: 10.1016/j.tiv.2016.02.018. Epub 2016
Feb 24. PubMed PMID: 26921666.

 

Allijn IE, Vaessen SF, Quarles van Ufford LC, Beukelman KJ, de Winther MP,
Storm G, Schiffelers RM. Head-to-Head Comparison of Anti-Inflammatory Performance
of Known Natural Products In Vitro.
PLoS One. 2016 May 10;11(5):e0155325. doi:
10.1371/journal.pone.0155325. eCollection 2016. PubMed PMID: 27163931; PubMed
Central PMCID: PMC4862632.

 

2015

Schiffelers MJ, Blaauboer BJ, Bakker WE, Hendriksen CF, Krul C. Regulatory
acceptance and use of the Extended One Generation Reproductive Toxicity Study
within Europe.
Regul Toxicol Pharmacol. 2015 Feb;71(1):114-24. doi:
10.1016/j.yrtph.2014.10.012. Epub 2014 Oct 28. PubMed PMID: 25445002.

 

2014

Westerhout J, van de Steeg E, Grossouw D, Zeijdner EE, Krul CA, Verwei M,
Wortelboer HM. A new approach to predict human intestinal absorption using
porcine intestinal tissue and biorelevant matrices.
Eur J Pharm Sci. 2014 Oct
15;63:167-77. doi:
http://10.1016/j.ejps.2014.07.003.
Epub 2014 Jul 18. PubMed PMID: 25046168.

 

Teunis MA, Spiekstra SW, Smits M, Adriaens E, Eltze T, Galbiati V, Krul C,
Landsiedel R, Pieters R, Reinders J, Roggen E, Corsini E, Gibbs S. International
ring trial of the epidermal equivalent sensitizer potency assay: reproducibility
and predictive-capacity.
ALTEX. 2014;31(3):251-68. doi:
http://dx.doi.org/10.14573/altex.1308021. Epub 2014 Feb 17. PubMed PMID:
24535238.

 

Vaessen SF, Bruysters MW, Vandebriel RJ, Verkoeijen S, Bos R, Krul CA,
Akkermans AM. Toward a mechanism-based in vitro safety test for pertussis toxin.
Hum Vaccin Immunother. 2014 May;10(5):1391-5. doi: 10.4161/hv.28001. Epub 2014
Feb 19. PubMed PMID: 24553455.

 

Ashton R, De Wever B, Fuchs HW, Gaca M, Hill E, Krul C, Poth A, Roggen EL.
State of the art on alternative methods to animal testing from an industrial
point of view: ready for regulation?
ALTEX. 2014;31(3):357-63. doi:
http://dx.doi.org/10.14573/altex1403121. Epub 2014 May 4. PubMed PMID: 24819539.

 

Schiffelers MJ, Blaauboer BJ, Bakker WE, Beken S, Hendriksen CF, Koeter HB,
Krul C. Regulatory acceptance and use of 3R models for pharmaceuticals and
chemicals: expert opinions on the state of affairs and the way forward. Regul
Toxicol Pharmacol. 2014 Jun;69(1):41-8. doi: 10.1016/j.yrtph.2014.02.007. Epub
2014 Feb 15. PubMed PMID: 24534000.

 

van der Linden SC, von Bergh AR, van Vught-Lussenburg BM, Jonker LR, Teunis M,
Krul CA
, van der Burg B. Development of a panel of high-throughput reporter-gene
assays to detect genotoxicity and oxidative stress.
Mutat Res Genet Toxicol
Environ Mutagen. 2014 Jan 15;760:23-32. doi: 10.1016/j.mrgentox.2013.09.009. Epub
2013 Dec 18. PubMed PMID: 24362253.

 

2012

Teunis M, Corsini E, Smits M, Madsen CB, Eltze T, Ezendam J, Galbiati V,
Gremmer E, Krul C, Landin A, Landsiedel R, Pieters R, Rasmussen TF, Reinders J,
Roggen E, Spiekstra S, Gibbs S. Transfer of a two-tiered keratinocyte assay:
IL-18 production by NCTC2544 to determine the skin sensitizing capacity and
epidermal equivalent assay to determine sensitizer potency. Toxicol In Vitro.
2013 Apr;27(3):1135-50. doi: 10.1016/j.tiv.2012.06.004. Epub 2012 Jun 19. PubMed
PMID: 22728231.