Ten Klooster JP, Sotiriou A, Boeren S, Vaessen S, Vervoort J, Pieters R. Type
2 diabetes-related proteins derived from an in vitro model of inflamed fat
Arch Biochem Biophys. 2018 Apr 15;644:81-92. doi:
10.1016/ Epub 2018 Mar 8. PubMed PMID: 29526533.

Barrea C, Vaessen S, Bulk S, Harvengt J, Misson JP. Phenotype-Genotype
Correlation in Children with Neurofibromatosis Type 1. Neuropediatrics. 2018
Jun;49(3):180-184. doi: 10.1055/s-0037-1620239. Epub 2018 Feb 22. PubMed PMID:

Agamennone V, Krul CAM, Rijkers G, Kort R. A practical guide for probiotics
applied to the case of antibiotic-associated diarrhea in The Netherlands.
Gastroenterol. 2018 Aug 6;18(1):103. doi: 10.1186/s12876-018-0831-x. PubMed PMID:
30078376; PubMed Central PMCID: PMC6091175.

Wagenaar L, Bol-Schoenmakers M, Giustarini G, Vonk MM, van Esch BCAM,
Knippels LMJ, Garssen J, Smit JJ, Pieters RHH. Dietary Supplementation with
Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose
Oral Immunotherapy in a Peanut Allergy Mouse Model.
Mol Nutr Food Res. 2018 Aug
13:e1800369. doi: 10.1002/mnfr.201800369. [Epub ahead of print] PubMed PMID:

Perusko M, van Roest M, Stanic-Vucinic D, Simons PJ, Pieters RHH, Cirkovic
Velickovic T, Smit JJ. Glycation of the Major Milk Allergen β-Lactoglobulin
Changes Its Allergenicity by Alterations in Cellular Uptake and Degradation.
Nutr Food Res. 2018 Sep;62(17):e1800341. doi: 10.1002/mnfr.201800341. Epub 2018
Jul 29. PubMed PMID: 30004175.

Koppelman SJ, Smits M, Tomassen M, de Jong GAH, Baumert J, Taylor SL, Witkamp
R, Veldman RJ, Pieters R, Wichers H. Release of Major Peanut Allergens from Their
Matrix under Various pH and Simulated Saliva Conditions-Ara h2 and Ara h6 Are
Readily Bio-Accessible
. Nutrients. 2018 Sep 11;10(9). pii: E1281. doi:
10.3390/nu10091281. PubMed PMID: 30208580.



Wang Y, Plastina P, Vincken JP, Jansen R, Balvers M, Ten Klooster JP, Gruppen
H, Witkamp R, Meijerink J. N-Docosahexaenoyl Dopamine, an Endocannabinoid-like
Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates
Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2. ACS

Chem Neurosci. 2017 Mar 15;8(3):548-557. doi: 10.1021/acschemneuro.6b00298. Epub
2016 Dec 6. PubMed PMID: 28292183.

Hiemstra PS, Grootaers G, van der Does AM, Krul CAM, Kooter IM. Human lung
epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and
future directions.
Toxicol In Vitro. 2018 Mar;47:137-146. doi:
10.1016/j.tiv.2017.11.005. Epub 2017 Nov 15. Review. PubMed PMID: 29155131.

Prinsen MK, Hendriksen CFM, Krul CAM, Woutersen RA. The Isolated Chicken Eye
test to replace the Draize test in rabbits.
Regul Toxicol Pharmacol. 2017
Apr;85:132-149. doi: 10.1016/j.yrtph.2017.01.009. Epub 2017 Feb 10. PubMed PMID:

Vonk MM, Wagenaar L, Pieters RHH, Knippels LMJ, Willemsen LEM, Smit JJ, van
Esch BCAM, Garssen J. The efficacy of oral and subcutaneous antigen-specific
immunotherapy in murine cow's milk- and peanut allergy models.
Clin Transl
Allergy. 2017 Sep 29;7:35. doi: 10.1186/s13601-017-0170-y. eCollection 2017.
PubMed PMID: 29021893; PubMed Central PMCID: PMC5622477.

Van Bilsen JHM, Sienkiewicz-Szłapka E, Lozano-Ojalvo D, Willemsen LEM,
Antunes CM, Molina E, Smit JJ, Wróblewska B, Wichers HJ, Knol EF, Ladics GS,
Pieters RHH, Denery-Papini S, Vissers YM, Bavaro SL, Larré C, Verhoeckx KCM,
Roggen EL. Application of the adverse outcome pathway (AOP) concept to structure
the available in vivo and in vitro mechanistic data for allergic sensitization to
food proteins.
Clin Transl Allergy. 2017 May 12;7:13. doi:
10.1186/s13601-017-0152-0. eCollection 2017. Review. PubMed PMID: 28507730;
PubMed Central PMCID: PMC5429547.

Vaessen SF, van Lipzig MM, Pieters RH, Krul CA, Wortelboer HM, van de Steeg E.
Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along
the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells.
Drug Metab
Dispos. 2017 Apr;45(4):353-360. doi: 10.1124/dmd.116.072231. Epub 2017 Feb 2.
PubMed PMID: 28153842.



Poland M, Ten Klooster JP, Wang Z, Pieters R, Boekschoten M, Witkamp R,
Meijerink J. Docosahexaenoyl serotonin, an endogenously formed n-3 fatty
acid-serotonin conjugate has anti-inflammatory properties by attenuating
IL-23-IL-17 signaling in macrophages.
Biochim Biophys Acta. 2016 Sep 20. pii:
S1388-1981(16)30249-9. doi: 10.1016/j.bbalip.2016.09.012. [Epub ahead of print]
PubMed PMID: 27663185.

Woutersen RA, Soffers AE, Kroese ED, Krul CA, van der Laan JW, van Benthem J,
Luijten M. Prediction of carcinogenic potential of chemicals using repeated-dose
(13-week) toxicity data.
Regul Toxicol Pharmacol. 2016 Sep 8;81:242-249. doi:
10.1016/j.yrtph.2016.09.003. [Epub ahead of print] PubMed PMID: 27614137.

Blaauboer BJ, Boobis AR, Bradford B, Cockburn A, Constable A, Daneshian M,
Edwards G, Garthoff JA, Jeffery B, Krul C, Schuermans J. Considering new
methodologies in strategies for safety assessment of foods and food ingredients.

Food Chem Toxicol. 2016 May;91:19-35. doi: 10.1016/j.fct.2016.02.019. Epub 2016
Mar 3. Review. PubMed PMID: 26939913.

Knipping K, van Roest M, Kruijssen L, Smits M, Teunis M, Cox L, de Jong N,
Simons PJ, Boon L, Teshima R, Gros M, Kegler D, Garssen J, Knippels LM, Pieters
. Intra- and inter-laboratory validation of an innovative huFcεRIα-RBL-2H3
degranulation assay for in vitro allergenicity assessment of whey hydrolysates.

Toxicol In Vitro. 2016 Jun;33:29-34. doi: 10.1016/j.tiv.2016.02.018. Epub 2016
Feb 24. PubMed PMID: 26921666.

Allijn IE, Vaessen SF, Quarles van Ufford LC, Beukelman KJ, de Winther MP,
Storm G, Schiffelers RM. Head-to-Head Comparison of Anti-Inflammatory Performance
of Known Natural Products In Vitro.
PLoS One. 2016 May 10;11(5):e0155325. doi:
10.1371/journal.pone.0155325. eCollection 2016. PubMed PMID: 27163931; PubMed
Central PMCID: PMC4862632.

Van der Wielen N, Ten Klooster JP, Muckenschnabl S, Pieters R, Hendriks HF,
Witkamp RF, Meijerink J. The Noncaloric Sweetener Rebaudioside A Stimulates
Glucagon-Like Peptide 1 Release and Increases Enteroendocrine Cell Numbers in
2-Dimensional Mouse Organoids Derived from Different Locations of the Intestine.

J Nutr. 2016 Dec;146(12):2429-2435. Epub 2016 Oct 26. PubMed PMID: 27798332.



Schiffelers MJ, Blaauboer BJ, Bakker WE, Hendriksen CF, Krul C. Regulatory
acceptance and use of the Extended One Generation Reproductive Toxicity Study
within Europe.
Regul Toxicol Pharmacol. 2015 Feb;71(1):114-24. doi:
10.1016/j.yrtph.2014.10.012. Epub 2014 Oct 28. PubMed PMID: 25445002.



Westerhout J, van de Steeg E, Grossouw D, Zeijdner EE, Krul CA, Verwei M,
Wortelboer HM. A new approach to predict human intestinal absorption using
porcine intestinal tissue and biorelevant matrices.
Eur J Pharm Sci. 2014 Oct
15;63:167-77. doi:
Epub 2014 Jul 18. PubMed PMID: 25046168.

Teunis MA, Spiekstra SW, Smits M, Adriaens E, Eltze T, Galbiati V, Krul C,
Landsiedel R, Pieters R, Reinders J, Roggen E, Corsini E, Gibbs S. International
ring trial of the epidermal equivalent sensitizer potency assay: reproducibility
and predictive-capacity.
ALTEX. 2014;31(3):251-68. doi: Epub 2014 Feb 17. PubMed PMID:

Vaessen SF, Bruysters MW, Vandebriel RJ, Verkoeijen S, Bos R, Krul CA,
Akkermans AM. Toward a mechanism-based in vitro safety test for pertussis toxin.
Hum Vaccin Immunother. 2014 May;10(5):1391-5. doi: 10.4161/hv.28001. Epub 2014
Feb 19. PubMed PMID: 24553455.

Ashton R, De Wever B, Fuchs HW, Gaca M, Hill E, Krul C, Poth A, Roggen EL.
State of the art on alternative methods to animal testing from an industrial
point of view: ready for regulation?
ALTEX. 2014;31(3):357-63. doi: Epub 2014 May 4. PubMed PMID: 24819539.

Schiffelers MJ, Blaauboer BJ, Bakker WE, Beken S, Hendriksen CF, Koeter HB,
Krul C. Regulatory acceptance and use of 3R models for pharmaceuticals and
chemicals: expert opinions on the state of affairs and the way forward. Regul
Toxicol Pharmacol. 2014 Jun;69(1):41-8. doi: 10.1016/j.yrtph.2014.02.007. Epub
2014 Feb 15. PubMed PMID: 24534000.

van der Linden SC, von Bergh AR, van Vught-Lussenburg BM, Jonker LR, Teunis M,
Krul CA
, van der Burg B. Development of a panel of high-throughput reporter-gene
assays to detect genotoxicity and oxidative stress.
Mutat Res Genet Toxicol
Environ Mutagen. 2014 Jan 15;760:23-32. doi: 10.1016/j.mrgentox.2013.09.009. Epub
2013 Dec 18. PubMed PMID: 24362253.



Teunis M, Corsini E, Smits M, Madsen CB, Eltze T, Ezendam J, Galbiati V,
Gremmer E, Krul C, Landin A, Landsiedel R, Pieters R, Rasmussen TF, Reinders J,
Roggen E, Spiekstra S, Gibbs S. Transfer of a two-tiered keratinocyte assay:
IL-18 production by NCTC2544 to determine the skin sensitizing capacity and
epidermal equivalent assay to determine sensitizer potency. Toxicol In Vitro.
2013 Apr;27(3):1135-50. doi: 10.1016/j.tiv.2012.06.004. Epub 2012 Jun 19. PubMed
PMID: 22728231.